Search results for "Digital ischemia"

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Is digital necrosis in COVID-19 caused by neutrophil extracellular traps: Potential therapeutic strategies

2021

Some of the COVID-19 patients present with ischemic lesions of their finger and toes. Standard anticoagulant therapy is usually unsuccessful for the treatment of this unique presentation of COVID-19. In this review current evidence is presented, which supports the hypothesis that these necrotic lesions are primarily related to the formation of neutrophil extracellular traps is blood vessels. Also, currently available and potential pharmaco-logical methods of the management of this unique thrombotic complication are discussed. Drugs that possibly could be used in COVID-19 patients suffering from acute ischemia of distal parts of the extremities particularly comprise DNase I and DNase1L3, whi…

Extracellular TrapsNecrosisNeutrophilsIschemiaPharmacologyExtracellular TrapsNeutrophil extracellular trapsArticleNecrosisDNaseAntithromboticmedicineExtracellularHumansDigital ischemiaSARS-CoV-2business.industryCOVID-19ThrombosisGeneral MedicineHeparinNeutrophil extracellular trapsmedicine.diseaseDipyridamolemedicine.symptombusinessmedicine.drugMedical Hypotheses

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PEPhysical Sciences and Engineering
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LSLife Sciences
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SHSocial Sciences and Humanities
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